FR-31564, a new phosphonic acid antibiotic: Bacterial resistance and membrane permeability.

In vitro synergism of FR-31564, a new phosphonic acid antibiotic.

Against most test strains of Gram-negative bacilli, the in vitro effect of FR-31564 together with beta-lactam antibiotics or trimethoprim was strongly synergistic; with tetracycline and nalidixic acid the effect was additive; and with gentamicin and sulfamethoxazole the effect was additive or antagonistic. FR-31564 was markedly synergistic with beta-lactam antibiotics against beta-lactam antibi...

Synergy of fosmidomycin (FR-31564) and other antimicrobial agents.

Fosmidomycin (FR-31564), a phosphonic acid derivative, was combined with cefazolin, cephalexin, ampicillin, carbenicillin, ticarcillin, gentamicin, and trimethoprim. Synergy between fosmidomycin and penicillins or cephalosporins was found for 37 to 52% of the Enterobacteriaceae tested. Synergy with trimethoprim was found against 55% of bacteria isolated, but only 17% of the strains showed syner...

antibiotic prescription and bacterial resistance

Essential Oils, A New Horizon in Combating Bacterial Antibiotic Resistance

For many years, the battle between humans and the multitudes of infection and disease causing pathogens continues. Emerging at the battlefield as some of the most significant challenges to human health are bacterial resistance and its rapid rise. These have become a major concern in global public health invigorating the need for new antimicrobial compounds. A rational approach to deal with anti...

Bacterial antibiotic resistance pdf

Two page summaries of cross-cutting and bacteriaspecific antibiotic resistance topics. The first section provides context and an overview of antibiotic resistance.Antimicrobial resistance: global report on surveillance. Resistance to antibacterial drugs in selected bacteria of international concern. Previously harmful agents that is known today as antimicrobial resistance. Currently antimicrobi...